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Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic , nodular lesions, which commonly appear on the trunk, arms and legs. [1] Patients often present with multiple excoriated nodules caused by chronic scratching.
Dryness, heat, cold, stress, and showering all exacerbate pruritus. Patients with this condition frequently have skin devoid of noticeable lesions. But in addition to xerosis, skin lesions like excoriation, crusts, impetigo, and prurigo nodularis may also develop as a result of repeated scratching. [4]
Lichen simplex chronicus (LSC) is thick leathery skin with exaggerated skin markings caused by sudden itching and excessive rubbing and scratching. [1] It generally results in small bumps, patches, scratch marks and scale. [1]
Nemolizumab was invented by Chugai, who sold an exclusive license for the drug's development and worldwide marketing (except Japan and Taiwan) to Galderma in 2016. [9]The US Food and Drug Administration (FDA) approved nemolizumab for the treatment of prurigo nodularis based on evidence from two clinical trials (OLYMPIA 1 and OLYMPIA 2) of 560 participants with prurigo nodularis. [4]
The efficacy and safety of dupilumab to treat prurigo nodularis among adults were evaluated in two clinical trials, EFC16459 (PRIME) and EFC16460 (PRIME2). [10] Each trial evaluated 300 mg of dupilumab administered every 2 weeks following an initial dose of 600 mg. [ 10 ] The treatment lasted for 24 weeks. [ 10 ]
The doctors and nurses didn’t believe Tomisa Starr was having trouble breathing. Two years ago, Starr, 61, of Sacramento, California, was in the hospital for a spike in her blood pressure.
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