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GAPDH Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI Identifiers Aliases GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase External IDs OMIM: 138400 ; MGI: 5434255 ; HomoloGene: 107053 ; GeneCards: GAPDH ; OMA: GAPDH - orthologs Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,534,512 bp End ...
Housekeeping genes account for majority of the active genes in the genome, and their expression is obviously vital to survival. The housekeeping gene expression levels are fine-tuned to meet the metabolic requirements in various tissues.
The American Cancer Society reports 5-year relative survival rates of over 70% for women with stage 0-III breast cancer with a 5-year relative survival rate close to 100% for women with stage 0 or stage I breast cancer. The 5-year relative survival rate drops to 22% for women with stage IV breast cancer. [3]
Cancer mortality rates are determined by the relationship of a population's health and lifestyle with their healthcare system. In the United States during 2013–2017, the age-adjusted mortality rate for all types of cancer was 189.5/100,000 for males, and 135.7/100,000 for females. [ 1 ]
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism.Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate.
These genes are often selected from housekeeping genes as their functions related to basic cellular survival normally imply constitutive gene expression. [ 5 ] [ 6 ] This enables researchers to report a ratio for the expression of the genes of interest divided by the expression of the selected normalizer, thereby allowing comparison of the ...
The following represent genes that should probably not be used for reference purposes: GUSB, [5] RPLP0, [5] TFRC, [5] GAPDH, HSP90, and β-actin. Although they were once considered as "housekeeping genes," recent data suggests that they are not as reliable as once thought. [1] [2]
The difference in disease-free survival rates (but not the overall survival rates) between individuals with PABC and ALIC was significant. [31] Further studies with larger numbers of patients are required to further define the features of ALIC and accurately compare its long-term prognosis to PACB as well as other breast cancer tumors. [1]
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