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Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. [21] Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause. [21] It may also be used to increase white blood cells for gathering during leukapheresis. [21]
The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. [citation needed] The Food and Drugs Administration (FDA) first approved filgrastim on February 20, 1991 marketed by Amgen with the brand name Neupogen. [31]
Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. [19] It serves to stimulate the production of white blood cells (neutrophils). [19] [21] Pegfilgrastim was developed by Amgen. [22]
In a couple of years, Amgen will have to face the music when the patent for its $4 billion a year drug, Neulasta, expires in the U.S. and Europe. The patent for sister drug Neupogen has already ...
Rank Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014 1 Adalimumab: Humira Biologic Rheumatoid arthritis: AbbVie Inc. 14,012 1,469
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Bill Gates told Patrick Collison that younger generations should worry about four things. They are the climate crisis, unchecked AI, nuclear war, and the spread of disease.
Sandoz's Zarxio is biosimilar to Amgen's Neupogen (filgrastim), which was originally licensed in 1991. This is the first product to be passed under the Biologics Price Competition and Innovation Act of 2009 (BPCI Act), which was passed as part of the Affordable Healthcare Act.
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