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Neuromuscular disease. A neuromuscular disease is any disease affecting the peripheral nervous system (PNS), [a] the neuromuscular junctions, or skeletal muscles, all of which are components of the motor unit. [4] Damage to any of these structures can cause muscle atrophy and weakness. Issues with sensation can also occur.
Muscular dystrophies ( MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause progressive weakness and breakdown of skeletal muscles over time. [ 1] The disorders differ as to which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. [ 1]
Distal muscular dystrophy, also called distal myopathy, is essentially any muscle disease that preferentially affects the hands and/or feet, a much less common pattern than proximal muscle weakness. Late adult-onset type 1; Late adult-onset type 2a; Late adult-onset type 2b; Early adult-onset type 1; Early adult-onset type 2; Early adult-onset ...
ALS is the most common motor neuron disease in adults and the third most common neurodegenerative disease [61] after Alzheimer's disease and Parkinson's disease. [119] Worldwide the number of people who develop ALS yearly is estimated to be 1.9 people per 100,000 per year, while the number of people who have ALS at any given time is estimated ...
Myasthenia gravis ( MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness. [ 1] The most commonly affected muscles are those of the eyes, face, and swallowing. [ 1][ 5] It can result in double vision, drooping eyelids, and difficulties in talking and walking. [ 1]
Progressive muscular atrophy ( PMA ), also called Duchenne–Aran disease and Duchenne–Aran muscular atrophy, is a disorder characterised by the degeneration of lower motor neurons, resulting in generalised, progressive loss of muscle function. PMA is classified among motor neuron diseases (MND) where it is thought to account for around 4% of ...
For Cooper Meshew, a rare and aggressive form of Charcot-Marie-Tooth (CMT), a degenerative nerve disease with muscle weakness, ... director of the Neuromuscular Clinic at Akron Children's, called ...
Degenerative disease. Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [1] In neurodegenerative diseases, cells of the central nervous system stop working or die via neurodegeneration.
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