Search results
Results from the WOW.Com Content Network
The osteoblasts are also connected by gap junctions, small pores that connect osteoblasts, allowing the cells in one cohort to function as a unit. [17] The gap junctions also connect deeper layers of cells to the surface layer ( osteocytes when surrounded by bone).
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Physiological bone resorption is an integral part of bone functioning, while the bone is constantly growing thanks to two processes — breakdown and formation of bone tissue. [23] Locally, it could be manifested in tooth eruption when the movement of a tooth follicle is followed by an active resorption of jaw bone tissue.
It invades the primary center of ossification, bringing osteogenic cells (osteoblasts on the outside, osteoclasts on the inside.) The canal of the nutrient foramen is directed away from more active end of bone when one end grows more than the other. When bone grows at same rate at both ends, the nutrient artery is perpendicular to the bone.
The mineralized matrix is penetrated by microvessel and numerous osteoblasts. The osteoblasts form new lamellar bone upon the recently exposed surface of the mineralized matrix. This new lamellar bone is in the form of trabecular bone. Eventually, all of the woven bone and cartilage of the original fracture callus is replaced by trabecular bone ...
During bone formation, an osteoblast is left behind and buried in the bone matrix as an "osteoid osteocyte", which maintains contact with other osteoblasts through extended cellular processes. [9] Although recently it was shown that vascular smooth muscle cells drive osteocyte differentiation [ 10 ] , most aspects of osteocytogenesis remain ...
Eventually, all of the cells within the nidus develop into, and display the morphologic characteristics of, an osteoblast. Then the osteoblasts create an extracellular matrix containing Type-I collagen fibrils, which is osteoid. The osteoblasts, while lining the periphery of the nidus, continue to form osteoid in the center of the nidus.
These osteoblasts are responsible for increasing the width of a long bone (the length of a long bone is controlled by the epiphyseal plate) and the overall size of the other bone types. After a bone fracture, the progenitor cells develop into osteoblasts and chondroblasts, which are essential to the healing process. The outer fibrous layer and ...