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Ly6 proteins are characterized by the LU domain.Typically, they contain one LU domain, but some members of the family have multiple LU domains.The LU domain consists of 60-80 AA and contains 10 cysteines arranged in a specific pattern that allows the creation of 5 disulfide bridges which in turn allow the formation of a three-fingered (3F) structural motif.
79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
A duplication of the gene has been detected in a case study of two individuals with severe intellectual disability, suggesting its role in proper brain development and cognitive function. [10] Additionally, the protein demonstrates high expression in several other normal organs including the testis , lungs , stomach , and prostate .
The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [5] [6] [7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [8]
72434 Ensembl ENSG00000124466 ENSMUSG00000057454 UniProt O95274 Q91YK8 RefSeq (mRNA) NM_014400 NM_133743 RefSeq (protein) NP_055215 NP_598504 Location (UCSC) Chr 19: 43.46 – 43.47 Mb Chr 7: 24.34 – 24.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ly6/PLAUR domain-containing protein 3 is a protein that in humans is encoded by the LYPD3 gene. References ^ a b c GRCh38: Ensembl ...
Sca-1 stands for "Stem cells antigen-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. [1] It is the common biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene. [5] [6] This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. [7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors. [8]