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TLR4 is the only TLR that uses all four adaptors. Complex consisting of TLR4, MD2 and LPS recruits TIR domain-containing adaptors TIRAP and MyD88 and thus initiates activation of NFκB (early phase) and MAPK. TLR4-MD2-LPS complex then undergoes endocytosis and in endosome it forms a signaling complex with TRAM and TRIF adaptors.
The first function described for TLR4 was the recognition of exogenous molecules from pathogens (PAMPs), in particular LPS molecules from gram-negative bacteria. [13] As pattern recognition receptor, TLR4 plays a fundamental role in pathogen recognition and activation of innate immunity which is the first line of defense against invading micro-organisms.
TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]
Toll-like receptor 1 (TLR1) is a member of the toll-like receptor (TLR) family of pattern recognition receptors (PRRs) that form the cornerstone of the innate immune system. [5] [6] [7] TLR1 recognizes bacterial lipoproteins and glycolipids in complex with TLR2. TLR1 is a cell surface receptor. [5]
Logo used until 2015. Samsung Galaxy (Korean: 삼성 갤럭시; stylized as SΛMSUNG Galaxy since 2015 (except Japan where it omitted the Samsung branding up until 2023), [2] previously stylized as Samsung GALAXY; abbreviated as SG) is a series of computing, Android mobile computing and wearable devices that are designed, manufactured and marketed by Samsung Electronics since 29 June 2009.
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. [5] TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system.
TLR4-IN-C34 (or C34) is a drug which acts as a potent and selective antagonist of Toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects.
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