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A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
The limit of detection (LOD or LoD) is the lowest signal, or the lowest corresponding quantity to be determined (or extracted) from the signal, that can be observed with a sufficient degree of confidence or statistical significance. However, the exact threshold (level of decision) used to decide when a signal significantly emerges above the ...
The hypothesis to be tested is if D is within the acceptable range of accuracy. Let L = the lower limit for accuracy and U = upper limit for accuracy. Then H 0 L ≤ D ≤ U. versus H 1 D < L or D > U. is to be tested. The operating characteristic (OC) curve is the probability that the null hypothesis is accepted when it is true.
Uncertainty quantification (UQ) is the science of quantitative characterization and estimation of uncertainties in both computational and real world applications. It tries to determine how likely certain outcomes are if some aspects of the system are not exactly known. An example would be to predict the acceleration of a human body in a head-on ...
Limit inferior and limit superior. In mathematics, the limit inferior and limit superior of a sequence can be thought of as limiting (that is, eventual and extreme) bounds on the sequence. They can be thought of in a similar fashion for a function (see limit of a function). For a set, they are the infimum and supremum of the set's limit points ...
There is another type of limit of a function, namely the sequential limit. Let f : X → Y be a mapping from a topological space X into a Hausdorff space Y, p ∈ X a limit point of X and L ∈ Y. The sequential limit of f as x tends to p is L if For every sequence (x n) in X − {p} that converges to p, the sequence f(x n) converges to L.
In logic, a quantifier is an operator that specifies how many individuals in the domain of discourse satisfy an open formula. For instance, the universal quantifier in the first order formula expresses that everything in the domain satisfies the property denoted by . On the other hand, the existential quantifier in the formula expresses that ...
In mathematical logic, a universal quantification is a type of quantifier, a logical constant which is interpreted as " given any ", " for all ", or " for any ". It expresses that a predicate can be satisfied by every member of a domain of discourse. In other words, it is the predication of a property or relation to every member of the domain.