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Lugol's iodine is a liquid made up of two parts potassium iodide for every one part elemental iodine in water. [8] Lugol's iodine was first made in 1829 by the French physician Jean Lugol. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] [10] Lugol's iodine is available as a generic medication and over the ...
It is advised to check the references for photos of reaction results. [1] Reagent testers might show the colour of the desired substance while not showing a different colour for a more dangerous additive. [2]
Gram noticed that some bacterial cells possessed noticeable resistance to decolorization. Based on these observations, Gram developed the initial gram staining procedure, initially making use of Ehrlich's aniline-gentian violet, Lugol's iodine, absolute alcohol for decolorization, and Bismarck brown for counterstain. [6]
The image on the right stains with Lugol's iodine, and identifies a squamous cell carcinoma, which does not pick up the stain. Chromoendoscopy is a medical procedure wherein dyes (often the same stains used in histology ) are instilled into the gastrointestinal tract at the time of visualization with fibre-optic endoscopy .
Hemiamyloidity in mycology refers to a special case of cell wall amyloidity where the blue staining by iodine only occurs when the tissue was pretreated with potassium hydroxide solution (KOH) or other strong bases, whereas direct application of iodine causes a red reaction when using Lugol's solution, but no reaction when using Melzer's reagent.
Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Pyrogallol use, e.g. in hair dye formulations, is declining because of concerns about its toxicity. [10] Its LD 50 (oral, rat) is 300 mg/kg. [3] Pure pyrogallol was found to be extremely genotoxic when inserted into cultured cells, but α amylase proteins protect against its toxicity during everyday exposure. [11] [12]
The dosing regime for the FDA-approved commercial 123 I-MIBG product Adreview is potassium iodide or Lugol's solution containing 100 mg iodide, weight adjusted for children and given an hour before injection. [18] EANM guidelines, endorsed by the SNMMI, suggest a variety of regimes in clinical use, for both children and adults. [9] [12]