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Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye, spelt and barley. [10]
For people with celiac disease, a lifelong strict gluten-free diet is the only effective treatment to date; [23] [69] For people diagnosed with non-celiac gluten sensitivity, there are still open questions concerning for example the duration of such a diet.
Coeliac disease (American English: celiac) (CD) is a chronic, immune-mediated, and mainly intestinal process, that appears in genetically predisposed people of all ages. It is caused by the ingestion of gluten, which is present in wheat, barley, rye and derivatives.
Getting diagnosed can take years and symptoms can mimic other ailments, but celiac is a serious autoimmune disease that can lead to heart disease, bowel cancer and potential infertility in women.
In 1924, Sidney V. Haas (1870–1964) described the first SCD for the treatment of children with celiac disease; this was known as the banana diet. [2] [3] Haas described a trial with 10 children; all 8 children treated with bananas went into remission, and the two control children died. [4]
Digestive conditions like GERD, acid reflux, Celiac disease and IBS negatively impact countless millions more. The genetic disorder cystic fibrosis is unique because it can cause both breathing ...
Celiac disease affects ~1% of the population in most parts of the world. [3] Ninety to one hundred percent of patients with coeliac disease have inherited genes at the HLA-DQ locus that encode HLA-DQ2 and/or HLA-DQ8 serotype proteins. [12] About 2–3% of individuals who inherit these HLA-DQ2 and/or HLA-DQ8 serotypes develop coeliac disease. [10]
Non-celiac gluten sensitivity (NCGS) is described as a condition of multiple symptoms that improves when switching to a gluten-free diet, after celiac disease and wheat allergy are excluded. [ 64 ] [ 65 ] Recognized since 2010, [ 66 ] [ 67 ] it is included among gluten-related disorders . [ 66 ]