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Transcription factor II H (TF II H) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TF II H first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an indispensable transcription factor ...
II.B Signal-dependent – may be either developmentally restricted in their expression or present in most or all cells, but all are inactive (or minimally active) until cells containing such proteins are exposed to the appropriate intra- or extracellular signal. II.B.1 Extracellular ligand (endocrine or paracrine)-dependent – nuclear receptors.
Transcription factor II H (TFIIH) is the key enzyme involved in dual excision. TFIIH and XPG are first recruited to the site of DNA damage (XPG stabilizes TFIIH). The TFIIH subunits of XPD and XPB act as a 5'-3' and 3'-5' helicase, respectively — they help unwind DNA and generate a junction between the double-stranded and single-stranded DNA ...
A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. [2] Constitutive upregulation of Myc genes have also been observed in carcinoma of the cervix, colon, breast, lung and stomach. [1] Myc is thus viewed as a promising target for anti-cancer drugs. [3]
Nutrient depletion induces TFEB dephosphorylation and subsequent nuclear translocation via the phosphatase calcineurin. [23] TFEB nuclear export is mediated by CRM1 and is dependent on phosphorylation. [24] [25] TFEB is also a target of the protein kinase AKT/PKB. [26] AKT/PKB phosphorylates TFEB at serine 467 and inhibits TFEB nuclear ...
EC 7.2.1 Translocation of inorganic cations linked to oxidoreductase reactions; EC 7.2.2 Translocation of inorganic cations linked to the hydrolysis of a nucleoside triphosphate; EC 7.2.4 Translocation of inorganic cations linked to decarboxylation; An important translocase contained in this group is Na+/K+ pump, also known as EC 7.2.2.13.
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 ... Transcription Factor II H; References Further reading ...
This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined.