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Transcription factor II H (TF II H) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TF II H first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an indispensable transcription factor ...
Transcription factor TF II A is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. [1] TF II A is one of several general (basal) transcription factors that are required for all transcription events that use RNA polymerase II. Other GTFs include TF II D, a complex composed of the TATA binding protein TBP and TBP ...
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. These transcription factors are critical to making sure that genes are expressed in the right cell at the right time and in the right amount, depending on the changing requirements of the organism.
229906 Ensembl ENSG00000137947 ENSMUSG00000028271 UniProt Q00403 P62915 RefSeq (mRNA) NM_001514 NM_145546 RefSeq (protein) NP_001505 NP_663521 Location (UCSC) Chr 1: 88.85 – 88.89 Mb Chr 3: 142.47 – 142.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ...
But, the majority of TBP is present in the B-TF II D complex, which is composed of TBP and TAFII170 in a 1:1 ratio. [5] TF II D and B-TF II D are not equivalent, since transcription reactions utilizing TF II D are responsive to gene specific transcription factors such as SP1, while reactions reconstituted with B-TF II D are not. [5]
This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. [1] It was assembled by manual curation. More detailed information is found in the manuscript and the web site accompanying the paper (Human Transcription Factors)
The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. They are involved in the Wnt signaling pathway , particularly during embryonic [ 2 ] and stem-cell development, [ 3 ] but also had been found to play a role in ...
TF II F is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. [4] [5] [6] TF II F binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF II F stabilizes the RNA polymerase II while it's contacting TBP and TF II B.