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1 in 10,000 people [2] Spinal muscular atrophy (SMA) is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle wasting. [3][4][5] It is usually diagnosed in infancy or early childhood and if left untreated it is the most common genetic cause of infant death. [6] It may also appear later in life and then ...
Spinal muscular atrophies. Spinal muscular atrophies (SMAs) are a genetically and clinically heterogeneous group of rare debilitating disorders characterised by the degeneration of lower motor neurons (neuronal cells situated in the anterior horn of the spinal cord) and subsequent atrophy (wasting) of various muscle groups in the body. [1]
The Singapore Medical Association (abbreviated SMA) is a professional association representing the interests of medical professionals in Singapore. It was established on September 15, 1959, replacing the Malaya Branch of the British Medical Association. [2] As of 2020, it had over 8,200 members. [3] It publishes the monthly peer-reviewed ...
Neurology. Distal spinal muscular atrophy type 1 (DSMA1), also known as spinal muscular atrophy with respiratory distress type 1 (SMARD1), is a rare neuromuscular disorder involving death of motor neurons in the spinal cord which leads to a generalised progressive atrophy of body muscles. The condition is caused by a genetic mutation in the ...
Death in Singapore. Graves at the Kranji War Cemetery – photographed on 13 November 2005. Deaths in Singapore offset the population increase from live births. In 2007, 17,140 people in Singapore died from various causes. The death rate was 4.5 deaths per 1,000 of the population. [1]
Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes. SMN is found in the cytoplasm of all animal cells and also in the nuclear gems. It functions in transcriptional regulation, telomerase regeneration and cellular trafficking. [2] SMN deficiency, primarily due to mutations in ...
Development of life expectancy in Singapore. As of 2019, Singaporeans have the world's longest life expectancy, 84.8 years at birth. Women can expect to live an average of 87.6 years with 75.8 years in good health. The averages for men are lower, with a life expectancy at 81.9 years with 72.5 years in good health. [5]
This first table gives a convenient overview of the general categories and broad causes. The leading cause is cardiovascular disease at 31.59% of all deaths. Rate of death by cause. Percent of all deaths. Category. Cause. Percent. Percent. I. Communicable, maternal, neonatal, and nutritional disorders.