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Febrile neutropenia or neutropenic fever is a defined as a single oral temperature value of ≥ 38.3 C (101 F) or a temperature ≥ 38 C (100.4 F) for ≥ 1 hour, with an absolute neutrophil count (ANC) < 1500 cell/microliter. [ 1] In case of severe neutropenia, the ANC is < 500 cell/microliter. [ 1] In profoundly severe neutropenia, the ANC is ...
Neutropenia. Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. [ 4] Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria, bacterial fragments and immunoglobulin -bound viruses in the blood. [ 5]
Neutropenic enterocolitis. Neutropenic enterocolitis, also known as typhlitis, is an inflammation of the cecum (part of the large intestine) that may be associated with infection. [ 1] It is particularly associated with neutropenia, a low level of neutrophil granulocytes (the most common form of white blood cells) in the blood.
Cyclic neutropenia (CyN), like severe congenital neutropenia (SCN), is a rare disorder. It is considered that in the general population, CyN has a frequency of one in one million. [ 1] It is the result of autosomal dominant mutation in ELANE gene located on the short arm (p) of chromosome 19 (19p13.3), the gene encoding neutrophil elastase ...
Leukopenia (from Greek λευκός (leukos) 'white' and πενία (penia) 'deficiency') is a decrease in the number of leukocytes ( WBC ). Found in the blood, they are the white blood cells, and are the body's primary defense against an infection. Thus the condition of leukopenia places individuals at increased risk of infection.
Severe congenital neutropenia ( SCN ), also often known as Kostmann syndrome or disease, is a group of rare disorders that affect myelopoiesis, causing a congenital form of neutropenia, usually without other physical malformations. SCN manifests in infancy with life-threatening bacterial infections. [ 2] It causes severe pyogenic infections.
Agranulocytosis. Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count ( leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. [ 1] It is a severe lack of one major class of infection-fighting white blood cells.
Sweet syndrome ( SS ), or acute febrile neutrophilic dermatosis, [ 1][ 2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination. The syndrome was first described in ...