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Neurology. Early-onset Alzheimer's disease ( EOAD ), also called younger-onset Alzheimer's disease ( YOAD ), [ 1] is Alzheimer's disease diagnosed before the age of 65. [ 2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are ...
Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
The mutation is extremely rare – it has only ever been found in two Swedish families and has never been found in the general population in any other countries. The mutation had important consequences for Alzheimer's disease research. The mutation occurs in the gene which encodes amyloid precursor protein (APP), which is proteolysed into beta ...
Amyloid beta. Amyloid beta ( Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [ 2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Education and professional qualifications. Rosser attended Jesus College, Cambridge (1968-1971); and King's College, Hospital Medical School (1971-1974). He holds a Bachelor of Medicine/ Bachelor of Surgery (1974); Master of Arts (1975); is a Member of the Royal College of Physicians (1976); Doctor of Medicine (1986); and Fellow of the Royal ...
Frontotemporal dementia ( FTD ), also called frontotemporal degeneration disease[ 1] or frontotemporal neurocognitive disorder,[ 2] encompasses several types of dementia involving the progressive degeneration of the brain's frontal and temporal lobes. [ 3] FTD is the second most prevalent type of early onset dementia after Alzheimer's disease ...
A neurodegenerative diseaseis caused by the progressive loss of neurons, in the process known as neurodegeneration. [2][3]Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system ...
Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. [6] [7] It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. [5]
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