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Neurology. Early-onset Alzheimer's disease ( EOAD ), also called younger-onset Alzheimer's disease ( YOAD ), [ 1] is Alzheimer's disease diagnosed before the age of 65. [ 2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are ...
Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
The mutation is extremely rare – it has only ever been found in two Swedish families and has never been found in the general population in any other countries. The mutation had important consequences for Alzheimer's disease research. The mutation occurs in the gene which encodes amyloid precursor protein (APP), which is proteolysed into beta ...
Frontotemporal dementia ( FTD ), also called frontotemporal degeneration disease[ 1] or frontotemporal neurocognitive disorder,[ 2] encompasses several types of dementia involving the progressive degeneration of the brain's frontal and temporal lobes. [ 3] FTD is the second most prevalent type of early onset dementia after Alzheimer's disease ...
A neurodegenerative diseaseis caused by the progressive loss of neurons, in the process known as neurodegeneration. [2][3]Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system ...
Education and professional qualifications. Rosser attended Jesus College, Cambridge (1968-1971); and King's College, Hospital Medical School (1971-1974). He holds a Bachelor of Medicine/ Bachelor of Surgery (1974); Master of Arts (1975); is a Member of the Royal College of Physicians (1976); Doctor of Medicine (1986); and Fellow of the Royal ...
Apolipoprotein E ( Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. [ 5] It is encoded in humans by the gene APOE . Apo-E belongs to a family of fat-binding proteins called apolipoproteins.
A demyelinating disease refers to any disease affecting the nervous system where the myelin sheath surrounding neurons is damaged. [ 1] This damage disrupts the transmission of signals through the affected nerves, resulting in a decrease in their conduction ability. Consequently, this reduction in conduction can lead to deficiencies in ...
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