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[6] [7] Although it can also cause weight gain, the risk is much lower than for other atypical antipsychotics. [8] How it works is not entirely clear but is believed to involve effects on serotonin and dopamine in the brain. [5] Ziprasidone was approved for medical use in the United States in 2001. [5]
Weight gain [18] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [ 19 ] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia , tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss.
Some atypicals are associated with considerable weight gain, diabetes and the risk of metabolic syndrome. [110] Unwanted side effects cause people to stop treatment, resulting in relapses. [111] Risperidone (atypical) has a similar rate of extrapyramidal symptoms to haloperidol (typical). [110]
Certain chemotherapies, steroids, hormonal medications like anti-estrogen treatments, antidepressants, or antipsychotics are known to cause weight gain. This means you may not see as much weight ...
The typical adult gains an average of 1 to 2 pounds per year, which over time, can contribute to obesity. This weight gain can be driven by physical inactivity, stress, poor sleep and poor food ...
In addition, the study was observational, meaning that it cannot prove cause, like that certain antidepressants cause weight gain or loss. Again, while researchers sought to focus on first-time ...
However, the H 1 receptor is linked to weight gain. To have partial agonism at the 5-HT 1A receptor can yield absence of weight gain in an antipsychotic. This is very relevant for ziprasidone, [105] [106] but it creates a risk for a prolonged QTc interval.
“Clinicians and patients can use this information, among other factors, to help decide on the right choice for them,” he added. Greatest risk of at least 5% weight gain at six months of use ...