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Chromium(III) nicotinate is an ionic substance used for chromium supplementation in some nutritional products, where it is also referred to as chromium polynicotinate. It appears in products that are referred to as a medical food used for nutritional support for conditions associated with diabetes mellitus type 2 .
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[2] [27] [28] [29] Two reviews concluded that chromium(III) picolinate may be more effective at lowering blood glucose levels compared to other chromium-containing dietary supplements. [ 28 ] [ 30 ] In 2005, the U.S. Food and Drug Administration (FDA) approved a qualified health claim for chromium picolinate as a dietary supplement relating to ...
Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body. [5] [6] It is a substrate in the Mitsunobu reaction. In the Hammick reaction, picolinic acid reacts with ketones to give pyridine-2-carbonols: [7] NC 5 H 4 CO 2 H + R 2 C=O → NC 5 H 4 CR 2 (OH) + CO 2
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A variety of other chromium(III) sulfates are known, but also contain hydroxide or oxide ligands. Most important commercially is basic chromium sulfate, which is thought to be [Cr 2 (H 2 O) 6 (OH) 4]SO 4 (CAS#39380-78-4). [2] It results from the partial neutralization of the hexahydrates. Other chromium(III) hydroxides have been reported. [3]
Trivalent chromium, or chromium(III), is an essential trace mineral in the human diet. [3] In some nutritional supplements, chromium(III) occurs as chromium(III) picolinate (in which chromium is bound to picolinic acid) or chromium(III) nicotinate (in which chromium is bound to nicotinic acid). Nicotinic acid is also known as the B vitamin niacin.
Chrome alum or Chromium(III) potassium sulfate is the potassium double sulfate of chromium. Its chemical formula is KCr(SO 4 ) 2 and it is commonly found in its dodecahydrate form as KCr(SO 4 ) 2 ·12(H 2 O).
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