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[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.
Chloroquine/proguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections. The major commercial manufacturer of mefloquine-based malaria treatment is Roche Pharmaceuticals, which markets the drug under the trade name Lariam. Lariam is fairly expensive at around three € per tablet (pricing of the year 2000).
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [51] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [52] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s)); [citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug. [1] Oral formulations (under trade name such as Endiaron [ 2 ] ) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment ...
Primaquine is well-absorbed in the gut and extensively distributed in the body without accumulating in red blood cells. Administration of primaquine with food or grapefruit juice increases its oral bioavailibity. [20] In blood, about 20% of circulating primaquine is protein-bound, with preferential binding to the acute phase protein orosomucoid ...
The drug is no longer recommended for use as a COVID treatment by major public health and medical organizations. Journal pulls scientific paper that popularized hydroxychloroquine as COVID-19 ...
Hydroxychloroquine and chloroquine have numerous, potentially serious, side effects, such as retinopathy, hypoglycemia, or life-threatening arrhythmia and cardiomyopathy. [26] Both drugs have extensive interactions with prescription drugs, affecting the therapeutic dose and disease mitigation. [26] [27] Some people have allergic reactions to ...
In March 2020, then US President Donald Trump promoted the use of chloroquine and hydroxychloroquine, two related anti-malarial drugs, for treating COVID-19. The FDA later clarified that it has not approved any therapeutics or drugs to treat COVID-19, but that studies were underway to see if chloroquine could be effective in treatment of COVID-19.