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Auto-brewery syndrome (ABS) (also known as gut fermentation syndrome, endogenous ethanol fermentation or drunkenness disease) is a condition characterized by the fermentation of ingested carbohydrates in the gastrointestinal tract of the body caused by bacteria or fungi. [1]
As little as 10 mL of pure methanol when drunk is metabolized into formic acid, which can cause permanent blindness by destruction of the optic nerve. 15 mL is potentially fatal, [1] although the median lethal dose is typically 100 mL (3.4 fl oz) (i.e. 1–2 mL/kg body weight of pure methanol). [4] Reference dose for methanol is 0.5 mg/kg/day. [9]
Alcohol intoxication typically begins after two or more alcoholic drinks. [5] Alcohol has the potential for abuse. Risk factors include a social situation where heavy drinking is common and a person having an impulsive personality. [5] Diagnosis is usually based on the history of events and physical examination. [6]
In 1940, Edward S. Dillon, W. Wallace, and Leon S. Smelo, first described alcoholic ketoacidosis as a distinct syndrome. They stated that "because of the many and complex factors, both physiologic and pathologic, which influence the acid-base balance of the body, a multitude of processes may bring about the state of acidosis as an end result". [7]
According to the Mayo Clinic, Stiff Person Syndrome is "a rare disorder of motor function characterized by involuntary stiffness of axial muscles and superimposed painful muscle spasms, which are ...
Symptoms of stiff person syndrome typically begin in the upper body, according to the Cleveland Clinic. As it progresses, symptoms typically move to the lower body, making it difficult to walk and ...
Substance intoxication is a transient condition of altered consciousness and behavior associated with recent use of a substance. [1] It is often maladaptive and impairing , but reversible. [ 2 ] If the symptoms are severe, the term "substance intoxication delirium " may be used. [ 3 ]
Celine Dion, who on Thursday announced she's battling Stiff Person Syndrome, has been diagnosed with an incurable neurological disease so extremely rare that, according to the famed Cleveland ...