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Aplastic anemia [2] (AA) [3] is a severe hematologic condition in which the body fails to make blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. [4] Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets. [5] [6]
Aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia, leukemia Agranulocytosis , also known as agranulosis or granulopenia , is an acute condition involving a severe and dangerous lowered white blood cell count ( leukopenia , most commonly of neutrophils ) and thus causing neutropenia in the circulating blood. [ 1 ]
Reticulocytopenia, or "aplastic crisis", is the medical term for an abnormal decrease of reticulocytes in the body The reticulocyte production index may find new use as a more reliable detector of erythropoietin-doping in athletes. The use of this method is referred to as "biological passport."
Aplastic anemia patients present with symptoms related to a decrease in hematopoietic cell production in the bone marrow. The onset is gradual, and the first symptom is frequently anemia or bleeding, though a high temperature or infections may be present at the onset. The following are examples of specific manifestations: [12]
Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells. [27] Autoimmune hemolytic anemia: D59.0-D59.1: Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction .
The following is a differential diagnosis for patients in which reticulocytopenia is the most marked cytopenia. For conditions that lead to significant reduction in all three cell lineages, see pancytopenia or aplastic anemia. Parvovirus B19 infection [5] Transient Erythroblastopenia of Childhood [4] Pure red cell aplasia [6]
This is a life-threatening disorder that is a characteristic of aplastic anemia. [3] There are also two general causes of cytopenia: autoimmune and refractory. Autoimmune cytopenia is caused by an autoimmune disease when your body produces antibodies to destroy the healthy blood cells.
This category reflects the organization of International Statistical Classification of Diseases and Related Health Problems, 10th Revision. Generally, diseases outlined within the ICD-10 codes D60-D61 within Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism should be included in this category.