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The Hill equation reflects the occupancy of macromolecules: the fraction that is saturated or bound by the ligand. [1] [2] [nb 1] This equation is formally equivalent to the Langmuir isotherm. [3] Conversely, the Hill equation proper reflects the cellular or tissue response to the ligand: the physiological output of the system, such as muscle ...
However, a series of publications by Popova and Sel'kov [2] derived the MWC rate equation for the reversible, multi-substrate, multi-product reaction. The same problem applies to the classic Hill equation which is almost always shown in an irreversible form. Hofmeyr and Cornish-Bowden first published the reversible form of the Hill equation. [1]
Download QR code; Print/export Download as PDF; Printable version; In other projects ... move to sidebar hide. Hill equation may refer to Hill equation (biochemistry) ...
The EC 10 and EC 90 concentrations to induce 10% and 90% maximal responses are defined similarly. There is a wide range of EC 50 values of drugs; they are typically anywhere from nM to mM. Hence, it is often more practical to refer to the logarithmically transformed p EC 50 values instead of EC 50 , where
Hill's equation is an important example in the understanding of periodic differential equations. Depending on the exact shape of (), solutions may stay bounded for all time, or the amplitude of the oscillations in solutions may grow exponentially. [3] The precise form of the solutions to Hill's equation is described by Floquet theory. Solutions ...
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None of the plaintiffs in the lawsuit is currently on the team. The eligibility of Green and Nickelberry expired after last season. The four others all transferred, many or all of them because ...
The first description of cooperative binding to a multi-site protein was developed by A.V. Hill. [4] Drawing on observations of oxygen binding to hemoglobin and the idea that cooperativity arose from the aggregation of hemoglobin molecules, each one binding one oxygen molecule, Hill suggested a phenomenological equation that has since been named after him: