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The timing hypothesis, gap hypothesis, gap theory, or critical window hypothesis for menopausal hormone therapy is a scientific theory that the benefits and risks of menopausal hormone therapy vary depending on the amount of time a woman has been in menopause upon initiation of treatment.
The Early versus Late Intervention Trial with Estradiol (ELITE) was a large randomized controlled trial that assessed the timing hypothesis that menopausal hormone therapy in early but not late menopause would improve cardiovascular outcomes.
The design of the hormone therapy trial (HT) was approached with the hypothesis that estrogen therapy would result in a decrease in coronary heart disease and osteoporosis-related fractures. As such, the primary outcome of interest was coronary heart disease, as this is a major cause of morbidity and mortality among women, particularly those ...
OPV AIDS hypothesis; ... Conversion therapy is the pseudoscientific practice of attempting to change ... (hormonal) castration, aversion therapy treatments such as ...
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ] [ 2 ] Effects of menopause can include symptoms such as hot flashes , accelerated skin aging, vaginal dryness , decreased muscle mass , and ...
The body is made up of more than 50 different kinds of hormones, according to the Cleveland Clinic, which makes it difficult to give blanket symptoms of a hormonal imbalance.
Menopausal hormone therapy has favorable effects on serum cholesterol levels, and when initiated immediately upon menopause may reduce the incidence of cardiovascular disease, although this hypothesis has yet to be tested in randomized trials. Estrogen appears to have a protector effect on atherosclerosis: it lowers LDL and triglycerides, it ...
“This research is especially hopeful following the recent failure of Truqap, a targeted therapy that had disappointing clinical trial results. It also offers a new hypothesis on why combining an ...
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