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The glomerular basement membrane is a special case, consisting of a fusion of the podocyte and endothelial basal laminas, and lacking a lamina reticularis. Thus, it consists of an especially thick lamina densa, sandwiched on its inside and outside by layers of lamina lucida / rara (one from each cell type).
Prostate gland microanatomy, with basement membrane annotated at bottom. As seen with the electron microscope, the basement membrane is composed of two layers, the basal lamina and the reticular lamina. [4] The underlying connective tissue attaches to the basal lamina with collagen VII anchoring fibrils and fibrillin microfibrils. [5]
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion. [1] [2]
Basal cells are bound to each other by desmosomes, and to the basal lamina of the basement membrane by hemidesmosomes. These junctions help to create one tightly bound, continuous tissue layer that can endure mechanical stress and effectively function as a connection between the basement membrane and remaining epithelial tissue. [4]
Keeping the basal epidermal keratinocytes attached to the basal lamina is vital for skin homeostasis. Genetic or acquired diseases that cause disruption of hemidesmosome components can lead to skin blistering disorders between different layers of the skin. These are collectively coined epidermolysis bullosa, or EB.
B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragma. Podocytes have primary processes called trabeculae, which wrap around the glomerular capillaries. [2]
The lamina lucida is a component of the basement membrane which is found between the epithelium and underlying connective tissue (e.g., epidermis and dermis of the skin). It is a roughly 40 nanometre wide electron-lucent zone between the plasma membrane of the basal cells and the (electron-dense) lamina densa of the basement membrane.