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The main toxin of curare, d-tubocurarine, occupies the same position on the receptor as ACh with an equal or greater affinity, and elicits no response, making it a competitive antagonist. The antidote for curare poisoning is an acetylcholinesterase (AChE) inhibitor (anti-cholinesterase), such as physostigmine or neostigmine. By blocking ACh ...
Tubocurarine is so-called because some of the plant extracts designated curare were stored, and subsequently shipped to Europe, in bamboo tubes. Likewise, curare stored in calabash containers was called calabash curare, although this was usually an extract not of Chondrodendron, but of the Strychnos species S. toxifera , containing a different ...
The "Dr. X" killings were a series of suspicious deaths by curare poisoning, in 1966 at a Bergen County, New Jersey hospital. [1] A newspaper investigation during the mid-1960s led to the indictment of an Argentina-born physician, Mario Enrique Jascalevich (August 27, 1927 — September 1984), in 1976.
Curare is a crude extract from certain South American plants in the genera Strychnos and Chondrodendron, originally brought to Europe by explorers such as Walter Raleigh [31] Edward Bancroft, a chemist and physician in the 16th century brought samples of crude curare from South America back to the Old-World.
curare Menispermaceae: It contains highly toxic alkaloids and is one of the sources of the arrow poison curare – specifically 'tube curare', the name of which is derived from the name of the medicinally valuable alkaloid tubocurarine. [82] Cicuta spp.
Menispermaceae (botanical Latin: 'moonseed family' from Greek mene 'crescent moon' and sperma 'seed') is a family of flowering plants.The alkaloid tubocurarine, a neuromuscular blocker and the active ingredient in the 'tube curare' form of the dart poison curare, is derived from the South American liana Chondrodendron tomentosum.
Curare is a generic term for arrow poisons that contain tubocurarine, curarine, quinine, protocurarine and related alkaloids. Most frequently it is derived from the bark of Strychnos toxifera , Strychnos guianensis (family Loganiaceae ), Chondrodendron tomentosum or Sciadotenia toxifera (family Menispermaceae ).
Curare was discovered in 1595, however toxiferine was only first isolated and characterized in 1941 by Wieland, Bähr and Witkop. [4] They managed to produce only a couple micrograms of this compound as it is quite hard to isolate in large enough quantities to study. This is due to the complexity of curare as it is composed of many different ...