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In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.This sequence mediates transcriptional termination by providing signals in the newly synthesized transcript RNA that trigger processes which release the transcript RNA from the transcriptional complex.
Intrinsic terminator containing an RNA hairpin rich in guanine and cytosine as well as a region high in uracil. The two types of termination signals in bacteria are intrinsic and factor-dependent terminators. [4] Intrinsic termination occurs when a specific sequence on the growing RNA strand elicits detachment of RNA polymerase from the RNA-DNA ...
Ter-binding proteins are found in some bacterial species, and include the Tus protein which is part of the common Ter-Tus binding domain. They are required for the termination of DNA replication and function by binding to DNA replication terminator sequences, thus preventing the passage of replication forks. [1]
Bacterial transcription is the process in which a segment of bacterial DNA is copied into a newly synthesized strand of messenger RNA (mRNA) with use of the enzyme RNA polymerase. The process occurs in three main steps: initiation, elongation, and termination; and the result is a strand of mRNA that is complementary to a single strand of DNA.
A ρ factor (Rho factor) is a bacterial protein involved in the termination of transcription. [1] Rho factor binds to the transcription terminator pause site, an exposed region of single stranded RNA (a stretch of 72 nucleotides) after the open reading frame at C-rich/G-poor sequences that lack obvious secondary structure.
The purpose function of intrinsic termination is to signal for the dissociation of the ternary elongation complex (TEC), ending the transcript. Intrinsic termination independent of the protein Rho , as opposed to Rho-dependent termination, where the bacterial Rho protein comes in and acts on the RNA polymerase, causing it to dissociate. [ 1 ]
The DNA strands are shown in pink and green.) Tus, also known as terminus utilization substance, is a protein that binds to terminator sequences and acts as a counter-helicase when it comes in contact with an advancing helicase. [2] The bound Tus protein effectively halts DNA polymerase movement. [2] Tus helps end DNA replication in prokaryotes ...
Although most operons in DNA are Rho independent, Rho dependent termination is also essential to maintain correct transcription. [ 1 ] ρ factor The Rho protein is an RNA translocase that recognizes a cytosine -rich region of the elongating mRNA, but the exact features of the recognized sequences and how the cleaving takes place remain unknown.