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Alpha-1 blocker, blocks alpha receptors and it relaxes the smooth muscles in the bladder. It helps the urine to flow smoothly and it can lessen the pain caused by the bladder pressing on the prostate. [44] [45] Selective alpha-1 blockers are better tolerated than non-selective alpha blockers in the body and therefore works better on BPH. [2]
When the term "alpha blocker" is used without further qualification, it can refer to an α 1 blocker, an α 2 blocker, a nonselective blocker (both α 1 and α 2 activity), or an α blocker with some β activity. [2] However, the most common type of alpha blocker is usually an α 1 blocker. Non-selective α-adrenergic receptor antagonists include:
Mechanism of Action of Alpha -1 blocker. Alpha 1 blocker exerts its action on alpha-1 receptor, dilating the smooth muscles. [3] Alpha-1 receptor is a Gq type G-protein coupled receptor. [3] When it is activated, it will lead to activation of phospholipase C, raising the intracellular level of IP3 and DAG. [3]
Pages in category "Alpha-1 blockers" The following 108 pages are in this category, out of 108 total. This list may not reflect recent changes. ...
This is a list of adrenergic drugs. These are pharmaceutical drugs , naturally occurring compounds and other chemicals that influence the function of the neurotransmitter epinephrine (adrenaline). Receptor ligands
Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [25] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [16]
The possibility for selective alpha 2 blockers to interact with non-target receptors, such as 5-HT serotonin receptors, can result in adverse effects, including weight gain and reduced movement due to serotonin receptor antagonism. [1] [9] Alpha 2 blockers are rarely utilised in clinical practice because of their substantial off-target binding ...
Carvedilol (used in congestive heart failure; it is a non-selective beta blocker) Chlorpromazine (antipsychotic and powerful antihypertensive) Doxazosin (used in hypertension and benign prostatic hyperplasia) Indoramin; Labetalol (used in hypertension; it is a mixed alpha/beta adrenergic antagonist) [19] Moxisylyte; Phenoxybenzamine