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  2. Tramadol - Wikipedia

    en.wikipedia.org/wiki/Tramadol

    A positron emission tomography imaging study found that single oral 50-mg and 100-mg doses of tramadol to human ... The drug tramadol is a racemate of the ...

  3. Desmetramadol - Wikipedia

    en.wikipedia.org/wiki/Desmetramadol

    (+)-Desmetramadol is a G-protein biased μ-opioid receptor full agonist. [4] It shows comparatively far lower affinity for the δ-and κ-opioid receptors. [5] The two enantiomers of desmetramadol show quite distinct pharmacological profiles; [6] both (+) and (−)-desmetramadol are inactive as serotonin reuptake inhibitors, [7] but (−)-desmetramadol retains activity as a norepinephrine ...

  4. List of side effects of tramadol - Wikipedia

    en.wikipedia.org/wiki/List_of_side_effects_of...

    Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite

  5. Hamilton's Pharmacopeia - Wikipedia

    en.wikipedia.org/wiki/Hamilton's_Pharmacopeia

    Hamilton travels there to study the drug and finds a dark history of medical experimentation. [7] " October 26, 2016 () 2: 2 "A Positive PCP Story — Hamilton travels across the USA meeting with addicts, dealers, chemists, and celebrities to trace the history of PCP from its pharmaceutical origins to its escape onto the streets. [8] "

  6. Dirty drug - Wikipedia

    en.wikipedia.org/wiki/Dirty_drug

    Examples of compounds often cited as "dirty drugs" include tramadol, chlorpromazine, olanzapine, dextromethorphan, ibogaine, and ethanol, all of which bind to multiple receptors or influence multiple receptor systems.

  7. Tapentadol - Wikipedia

    en.wikipedia.org/wiki/Tapentadol

    Given that tapentadol is a highly selective full agonist of the μ-opioid receptor, and given that is not a pro-drug, with a relatively high ceiling effect, studies have found that it is significantly more abusable than tramadol, [39] and similar to hydrocodone and other full agonists of the μ-opioid receptor (such as oxycodone and ...

  8. Peripherally acting μ-opioid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Peripherally_acting_μ...

    Even though μ-opioid receptor (MOR) targeting drugs have been used for a long time, not much is known about the structure-activity relationship and the ligand-receptor interactions on the basis of well-defined biological effects on receptor activation or inhibition. Also, the distinction in the receptor-ligand interaction patterns of agonists ...

  9. Celecoxib/tramadol - Wikipedia

    en.wikipedia.org/wiki/Celecoxib/tramadol

    Celecoxib/tramadol sold under the brand name Seglentis, is a fixed-dose combination of the anti-inflammatory celecoxib and the opioid tramadol used for the management and treatment of pain. [ 1 ] Developed by Spanish pharmaceutical company Esteve , it was approved for medical use in the United States in October 2021.

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