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Standard phenylalanine concentrations in unaffected persons are about 2-6mg/dl (120–360 μmol/L) phenylalanine concentrations in those with untreated hyperphenylalaninemia can be up to 20 mg/dL (1200 μmol/L). Measurable IQ deficits are often detected as phenylalanine levels approach 10 mg/dL (600 mol/L).
The aspartame-cancer connection ... Diet soda is also incredibly sweet, notes Mangano, and sweetness causes pleasure centers in the brain to light up. “People get a good feeling when they taste ...
Animal studies in the 1980s showed no cancer-causing effects from aspartame, even in high doses, and no damage to DNA. Studies over the years, however, have raised a red flag on a potential link ...
In July 2023, the WHO’s International Agency for Research on Cancer classified one synthetic sweetener, aspartame, as “possibly carcinogenic to humans,” although the US Food and Drug ...
The artificial sweetener aspartame has been the subject of several controversies since its initial approval by the U.S. Food and Drug Administration (FDA) in 1974. The FDA approval of aspartame was highly contested, beginning with suspicions of its involvement in brain cancer, [1] alleging that the quality of the initial research supporting its safety was inadequate and flawed, and that ...
However, this very practice of excluding phenylalanine from the diet was not working for other forms of HPA. This was attributed to a deficiency of tetrahydrobiopterin (BH4), a cofactor for PAH. [14] The most common form of BH4 deficiency is due to PTPS. Later on PTPS was discovered and it was learned that PKU causes HPA but not all HPA is PKU ...
It’s not clear how aspartame could potentially cause cancer. Jotham Suez, a molecular microbiologist and immunologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore, said ...
Tetrahydrobiopterin deficiency (THBD, BH 4 D) is a rare metabolic disorder that increases the blood levels of phenylalanine.Phenylalanine is an amino acid obtained normally through the diet, but can be harmful if excess levels build up, causing intellectual disability and other serious health problems.