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Both GAD 67 and GAD 65 are also regulated post-translationally by pyridoxal 5’-phosphate (PLP); GAD is activated when bound to PLP and inactive when not bound to PLP. [23] Majority of GAD 67 is bound to PLP at any given time, whereas GAD 65 binds PLP when GABA is needed for neurotransmission. [ 23 ]
Gaëtan Dugas (French: [ɡaetɑ̃ dyɡa]; February 20, 1953 – March 30, 1984) was a Canadian flight attendant whose role in the early years of the AIDS epidemic attracted considerable attention. Initially identified as a central figure labeled " Patient Zero ", Dugas faced allegations of being a primary source of HIV transmission to the ...
key:ayxypkufhzrooj-zetcqymhsa-n (verify) Pregabalin , sold under the brand name Lyrica among others, is an anticonvulsant , analgesic , and anxiolytic amino acid medication used to treat epilepsy , neuropathic pain , fibromyalgia , restless legs syndrome , opioid withdrawal , and generalized anxiety disorder (GAD).
In another example, male mice were socially isolated as a form of stress. Offspring of these mice had increased anxiety in response to stressful conditions, increased stress hormone levels, dysregulation of the HPA axis which plays a key role in stress response, and several other characteristics that indicated increased sensitivity to stress.
A clinical formulation, also known as case formulation and problem formulation, is a theoretically-based explanation or conceptualisation of the information obtained from a clinical assessment. It offers a hypothesis about the cause and nature of the presenting problems and is considered an adjunct or alternative approach to the more ...
For example, as of 2006, diltiazem hydrochloride had four equivalence groups, all using the same active ingredient, but considered equivalent only within each group. [46] In order to start selling a drug promptly after the patent on innovator drug expires, a generic company has to file its ANDA well before the patent expires.
Example of cosmetic gels Topical gels are commonly used as sustained release dosage forms . [ 5 ] [ 9 ] Usage of the sustained release dosage form reduces the administration of recurrent doses while maintaining serum dose levels at the therapeutic range (difference between toxic and therapeutic doses), hence improving patient compliance .
Key Word In Context (KWIC) is the most common format for concordance lines. The term KWIC was coined by Hans Peter Luhn . [ 1 ] The system was based on a concept called keyword in titles , which was first proposed for Manchester libraries in 1864 by Andrea Crestadoro .