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Both GAD 67 and GAD 65 are also regulated post-translationally by pyridoxal 5’-phosphate (PLP); GAD is activated when bound to PLP and inactive when not bound to PLP. [23] Majority of GAD 67 is bound to PLP at any given time, whereas GAD 65 binds PLP when GABA is needed for neurotransmission. [ 23 ]
Gaëtan Dugas (French: [ɡaetɑ̃ dyɡa]; February 20, 1953 – March 30, 1984) was a Canadian flight attendant whose role in the early years of the AIDS epidemic attracted considerable attention. Initially identified as a central figure labeled " Patient Zero ", Dugas faced allegations of being a primary source of HIV transmission to the ...
In pharmacy, a formulation is a mixture or a structure such as a capsule, tablet, or an emulsion, prepared according to a specific procedure (called a "formula")."). Formulations are a very important aspect of creating medicines, since they are essential to ensuring that the active part of the drug is delivered to the correct part of the body, in the right concentration, and at the right rate ...
Formulation terminology follows a 2-letter convention: (e.g. GR: granules) listed by CropLife International (formerly GIFAP then GCPF) in the Catalogue of Pesticide Formulation Types (Monograph 2); see: download page. Some manufacturers do not follow these industry standards, which can cause confusion for users.
In another example, male mice were socially isolated as a form of stress. Offspring of these mice had increased anxiety in response to stressful conditions, increased stress hormone levels, dysregulation of the HPA axis which plays a key role in stress response, and several other characteristics that indicated increased sensitivity to stress.
A clinical formulation, also known as case formulation and problem formulation, is a theoretically-based explanation or conceptualisation of the information obtained from a clinical assessment. It offers a hypothesis about the cause and nature of the presenting problems and is considered an adjunct or alternative approach to the more ...
The term dosage form may also sometimes refer only to the pharmaceutical formulation of a drug product's constituent substances, without considering its final configuration as a consumable product (e.g., capsule, patch, etc.). Due to the somewhat ambiguous nature and overlap of these terms within the pharmaceutical industry, caution is ...
Magnevist is the most widespread example. [ 33 ] [ 34 ] Nanotubes packed with gadolinium, called " gadonanotubes ", are 40 times more effective than the usual gadolinium contrast agent. [ 35 ] Traditional gadolinium-based contrast agents are un-targeted, generally distributing throughout the body after injection, but will not readily cross the ...