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Promyelocytes measure 12–20 microns in diameter. The nucleus of a promyelocyte is approximately the same size as a myeloblast but their cytoplasm is much more abundant. [1] They also have less prominent nucleoli than myeloblasts and their chromatin is more coarse and clumped. [1] The cytoplasm is basophilic and contains primary red/purple ...
Atypical promyelocytes show poor cytoplasmic granularity. Auer's rods are found in some cells. Nuclei have a characteristic morphology in the form of "butterflies".
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Date: 29 November 2022: Source: Own work: Author: Mikael Häggström, M.D. Author info - Reusing images - Conflicts of interest: None Mikael Häggström, M.D. Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance).
Chronic myelomonocytic leukemia (CMML) is a type of leukemia, which are cancers of the blood-forming cells of the bone marrow.In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis.
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 June 2024. Abnormal blood cells in hypergranular APML A faggot cell (bottom left of the central cell cluster) with a prominent collection of Auer rods from a patient with acute promyelocytic leukemia. Faggot cells are cells normally found in the hypergranular form of acute promyelocytic leukemia (FAB ...
A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.
Myeloblast with an Auer rod (to the left of the nucleus).. Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, high-grade myelodysplastic syndromes and myeloproliferative disorders.