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A promyelocyte (or progranulocyte) is a granulocyte precursor, developing from the myeloblast and developing into the myelocyte. Promyelocytes measure 12–20 microns in diameter. The nucleus of a promyelocyte is approximately the same size as a myeloblast but their cytoplasm is much more abundant. [1]
The nuclear chromatin is coarser than that observed in a promyelocyte, but it is relatively faintly stained and lacks a well-defined membrane. The nucleus is fairly regular in contour (not indented), and seems to be 'buried' beneath the numerous cytoplasmic granules. (If the nucleus were indented, it would likely be a metamyelocyte.)
A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.
The next developmental stage, a promyelocyte, still has a large oval nucleus, but there is more cytoplasm in the cell at this point, also cytoplasmic granules are beginning to form. The development of granules continues with the next stage, a myelocyte. At this point, the nucleus is starting to shrink.
In hematology, myelopoiesis in the broadest sense of the term is the production of bone marrow and of all cells that arise from it, namely, all blood cells. [1] In a narrower sense, myelopoiesis also refers specifically to the regulated formation of myeloid leukocytes (), including eosinophilic granulocytes, basophilic granulocytes, neutrophilic granulocytes, and monocytes.
A metamyelocyte is a cell undergoing granulopoiesis, derived from a myelocyte, and leading to a band cell. It is characterized by the appearance of a bent nucleus, cytoplasmic granules, and the absence of visible nucleoli. (If the nucleus is not yet bent, then it is likely a myelocyte.)
myeloblast, promyelocyte, myelocyte, metamyelocyte: Mast cell: Helper T cell: Regulatory T cell: Cytotoxic T cell: Natural killer T cell: B cell(/lymphocyte)
Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Comprehensive diagram that shows the development of different blood cells from haematopoietic stem cell to mature cells in both myeloid and lymphoid lineages.