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The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the most recent analyses suggesting that, when initiated within 10 years of menopause, HRT reduces all-cause mortality and risks of coronary disease, osteoporosis, and dementia; after 10 years the beneficial effects on mortality and coronary ...
In 2000, more than one in five women over 50 were taking hormones, according to statistics tracked by the Menopause Society, an influential health-care nonprofit. By 2008, fewer than 5 percent of ...
Its goal is to mitigate discomfort caused by diminished circulating estrogen after menopause. The 2002 Women's Health Initiative of the National Institutes of Health found disparate results for all cause mortality with hormone replacement, finding it to be lower when HRT was begun earlier, between age 50–59, but higher when begun after age 60.
Hormone replacement therapy (HRT) should be offered as the first treatment to ease menopause symptoms such as hot flushes and night sweats, according to the latest advice from health watchdog NICE
Estrone is an estrogen, specifically an agonist of the estrogen receptors (ERs) ERα and ERβ. [5] [44] It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. [5] [44] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [45]
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The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. [11] [12] These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after menopause.
After menopause, when estrogen levels drop, the risk of heart disease in women goes up and becomes higher than in men of the same age.” Estrogen protects the cardiovascular system in several ways.
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