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While a 2018 review found that taking progesterone and estrogen together can decrease this risk, [53] other reviews reported an increased risk of blood clots and pulmonary embolism when estrogen and progestogen were combined, particularly when treatment was started 10 years or more after menopause and when the women were older than 60 years ...
Its goal is to mitigate discomfort caused by diminished circulating estrogen after menopause. The 2002 Women's Health Initiative of the National Institutes of Health found disparate results for all cause mortality with hormone replacement, finding it to be lower when HRT was begun earlier, between age 50–59, but higher when begun after age 60.
After menopause, when estrogen levels drop, the risk of heart disease in women goes up and becomes higher than in men of the same age.” Estrogen protects the cardiovascular system in several ways.
A 2024 study in Menopause that analyzed 13 years of medical records of a staggering 10 million older women found that those who were still on estrogen-only HT after 65 were 20% less likely to die ...
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The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. [11] [12] These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after menopause.
[111] [112] Whereas the risk of cardiovascular death is 0.06 per 100,000 in women who are age 15 to 34 years, are taking a combined oral contraceptive, and do not smoke, this increases by 50-fold to 3.0 per 100,000 in women who are age 35 to 44 years, are taking a combined oral contraceptive, and do not smoke.
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