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The pharmacokinetics of cetirizine have been found to increase linearly with dose across a range of 5 to 60 mg. [3] Its C max following a single dose has been found to be 257 ng/mL for 10 mg and 580 ng/mL for 20 mg. [2] Food has no effect on the bioavailability of cetirizine but has been found to delay the T max by 1.7 hours (i.e., to ...
The first six characters of the GPI define the therapeutic class code, the next two pairs the drug name, and the last four define route, dosage or strength. For example GPI 58-20-00-60-10-01-05 is for the drug nortriptyline HCl cap 10 mg (an antidepressant ) and can be further classified as follows: [ 1 ]
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Cetirizine, although less sedating, is non-dialyzable and possesses similar antihistamine properties. The other metabolites identified include a N -dealkylated metabolite, and an O -dealkylated 1/16 metabolite with a plasma half-life of 59 hours.
Levocetirizine is an antihistamine. It acts as an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increases the blood supply to the area, providing relief from the typical symptoms of hay fever.
For this reason, producers of drugs such as OTC analgesics wanting to emphasize the strength of their product developed the "caplet", a portmanteau [6] of capsule-shaped tablet, [7] [8] in order to tie this positive association to more efficiently produced tablet pills as well as being an easier-to-swallow shape than the usual disk-shaped tablet.
Piperoxan was discovered in 1933 and was the first compound with antihistamine effects to be identified. [22] Piperoxan and its analogues were too toxic to be used in humans. [ 22 ] Phenbenzamine (Antergan) was the first clinically useful antihistamine and was introduced for medical use in 1942. [ 22 ]
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related to: cetirizine 10mg tablets picture of pill identifier chart