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Treatment of such infections can be difficult due to multiple antibiotic resistance, [4] and in the United States, there was an increase in MDRPA (Multidrug-resistant Pseudomonas aeruginosa) resistant to ceftazidime, ciprofloxacin, and aminoglycosides, from 0.9% in 1994 to 5.6% in 2002. [5]
The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa. [citation needed] There are three ureidopenicillins in clinical use: [1] Azlocillin; Piperacillin; Mezlocillin; They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas.
On the rare occasions where infection is superficial and limited (for example, ear infections or nail infections), topical gentamicin or colistin may be used. [ citation needed ] For pseudomonal wound infections, acetic acid with concentrations from 0.5% to 5% can be an effective bacteriostatic agent in eliminating the bacteria from the wound.
Pseudomonas aeruginosa is highly contagious and has displayed resistance to antibiotic treatments, making it difficult to manage effectively. Some strains of Pseudomonas are known to target white blood cells in various mammal species , posing risks to humans, cattle, sheep, and dogs alike.
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections. [5] This includes bone and joint infections, intra-abdominal infections, certain types of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. [5]
Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient level, the boosted antimicrobial potency provided by synergy allows the body to more rapidly clear infections, resulting in shorter courses of antibiotic therapy. [3] Shorter courses of therapy in turn reduce the effects of dose-related toxicity, if applicable ...
Dicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. [1] It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria. [1] It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.
Hospitalized patients without risk for Pseudomonas: This group requires intravenous antibiotics, with a quinolone active against Streptococcus pneumoniae (such as levofloxacin), a β-lactam antibiotic (such as cefotaxime, ceftriaxone, ampicillin/sulbactam or high-dose ampicillin plus a macrolide antibiotic (such as azithromycin or ...