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Low protein diets rapidly reduce fat and restores normal insulin sensitivity to diet-induced obese mice. [15] Specifically restricting consumption of the three branched-chain amino acids leucine, isoleucine and valine is sufficient to promote leanness and improve regulation of blood glucose. [ 16 ]
Increased stress sensitivity: Male offspring of pregnant rats fed low-protein diets have been shown to exhibit blood pressure that is hyperresponsive to stress and salt. [12] Decreased sperm quality: A low-protein diet during gestation in rats has been shown to affect the sperm quality of the male offspring in adulthood.
In diet-induced obese and insulin resistant mice, a diet with decreased levels of isoleucine (with or without the other branched-chain amino acids) results in reduced adiposity and improved insulin sensitivity. [7] [8] Reduced dietary levels of isoleucine are required for the beneficial metabolic effects of a low protein diet. [8]
A transcriptome-wide analysis in mice found that a protein-restricted (PR) diet during gestation resulted in differential gene expression in approximately 1% of the fetal genes analyzed (235/22,690). Specifically, increased expression was seen in genes involved in the p53 pathway, apoptosis , negative regulators of cell metabolism, and genes ...
While high-protein diets on social media often showcase people eating as much as 140 grams of protein per day, the actual amount you need is far less.
When leptin levels drop, the body interprets this as a loss of energy, and hunger increases. Mice lacking this protein eat until they are four times their normal size. Leptin, however, plays a different role in diet-induced obesity in rodents and humans. Because adipocytes produce leptin, leptin levels are elevated in the obese.
Calorie restriction (also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. [ 1 ] [ 2 ] The possible effect of calorie restriction on body weight management , longevity , and aging-associated diseases has been an active area of research.
PEMT deficiency prevents atherosclerosis in mice fed high-fat, high-cholesterol diets. [33] This is largely a result of lower levels of VLDL lipids in the PEMT-deficient mice. [34] Furthermore, the decreased lipid (PC) content in VLDLs causes changes in lipoprotein structure which allow them to be cleared more rapidly in the PEMT-deficient mice ...
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