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Ephedra is widely used by athletes as a performance-enhancing drug, [13] despite a lack of evidence that it improves athletic performance. [14] [15] Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine. [16] Ephedra has been used as a weight-loss aid, sometimes in combination with aspirin and caffeine.
Ephedra is a genus of gymnosperm shrubs.The various species of Ephedra are widespread in many arid regions of the world, ranging across southwestern North America, southern Europe, northern Africa, southwest and central Asia, northern China and western South America. [2]
Ephedra spp. is used as a diuretic, as a treatment for urinary tract infections, for asthma, and as stimulant due to the presence of ephedrine and other compounds. [citation needed] The sale of dietary supplements containing ephedra has been banned in the United States due to the risk of serious adverse events or death. [5]
The pure alkaloid ephedrine from the Ephedra herbs is popular for effective medicine for asthma, especially because it can be given by mouth unlike adrenaline. [ 8 ] Ephedrine products are banned in U.S.A since 1994 for causing various and serious adverse effects, such as headache, insomnia, stroke, arrhythmias , myocardial infarction ...
Along with ephedrine, pseudoephedrine occurs naturally in ephedra, which has been used for thousands of years in traditional Chinese medicine. [13] [28] It was first isolated from ephedra in 1889. [28] [13] [29] Subsequent to its synthesis in the 1920s, pseudoephedrine was introduced for medical use as a decongestant. [13]
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Ephedrine in its natural form, known as máhuáng (麻黄) in traditional Chinese medicine, has been documented in China since the Han dynasty (206 BC – 220 AD) as an antiasthmatic and stimulant. [65] In traditional Chinese medicine, máhuáng has been used as a treatment for asthma and bronchitis for centuries. [66]
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