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Spinocerebellar ataxia (SCA) is a progressive, degenerative, [1] genetic disease with multiple types, each of which could be considered a neurological condition in its own right. An estimated 150,000 people in the United States have a diagnosis of spinocerebellar ataxia at any given time .
Ataxin 1 like has reduced expression in transgenic mice models and has been shown to moderate cytotoxicity of ataxin-1. [30] Toxicity from the mutated protein causes degradation in neural tissues. This includes loss of dendritic aborization, or branching, early in disease progression and eventual atrophy of brain tissues in later stages. [21]
The Boston Diagnostic Aphasia Examination provides a comprehensive exploration of a range of communicative abilities. Its results are used to classify patient's language profiles into one of the localization based classifications of aphasia: Broca's, Wernicke's, anomic, conduction, transcortical, transcortical motor, transcortical sensory, and global aphasia syndromes, although the test does ...
The Boston Naming Test (BNT), introduced in 1983 by Edith Kaplan, Harold Goodglass and Sandra Weintraub, is a widely used neuropsychological assessment tool to measure confrontational word retrieval in individuals with aphasia or other language disturbance caused by stroke, Alzheimer's disease, or other dementing disorder. [1]
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The CAT was published in 2005 and was the first new aphasia test in English for 20 years. The test is designed to (1) screen for associated cognitive deficits,(2) assess language impairment in people with aphasia, (3) investigate the consequences of the aphasia on the individual's lifestyle and emotional well-being, and (4) monitor changes in ...
Mixed transcortical aphasia is characterized by severe speaking and comprehension impairment, but with preserved repetition. [6] People who suffer mixed transcortical aphasia struggle greatly to produce propositional language or to understand what is being said to them, yet they can repeat long, complex utterances or finish a song once they hear the first part.
FRDA is the most prevalent inherited ataxia, affecting approximately 1 in 40,000 with European descent. [15] Males and females are affected equally. The estimated carrier prevalence is 1:100. [5] A 1990–1996 study of Europeans calculated the incidence rate was 2.8:100,000. [40] The prevalence rate of FRDA in Japan is 1:1,000,000. [41]
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