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Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. [2] In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). [3] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells.
It is well known that stromal cells arise and are stored in the bone marrow until maturation and differentiation. They are located in the stroma and aid hematopoietic cells in forming the elements of the blood. [8] While a majority is found in the bone marrow scientists now know that stromal cells can be found in a variety of different tissues ...
Stroma (tissue), the connective, functionally supportive framework of a biological cell, tissue, or organ (in contrast, the parenchyma is the functional aspect of a tissue) Stroma of ovary, a soft tissue, well supplied with blood, consisting of spindle-shaped cells with a small amount of connective tissue; Stroma of iris, fibres and cells in ...
The cells which make up stroma tissues serve as a matrix in which the other cells are embedded. [2] Stroma is made of various types of stromal cells. Examples of stroma include: stroma of iris; stroma of cornea; stroma of ovary; stroma of thyroid gland; stroma of thymus; stroma of bone marrow; lymph node stromal cell; multipotent stromal cell ...
Myeloma bone disease is due to the overexpression of receptor activator for nuclear factor κ B ligand by bone marrow stroma. RANKL activates osteoclasts , which resorb bone. The resultant bone lesions are lytic (cause breakdown) in nature, and are best seen in plain radiographs, which may show "punched-out" resorptive lesions (including the ...
Hematopoietic stem cells (HSCs) are the stem cells [1] that give rise to other blood cells.This process is called haematopoiesis. [2] In vertebrates, the first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition.
947 12490 Ensembl ENSG00000174059 ENSMUSG00000016494 UniProt P28906 Q64314 RefSeq (mRNA) NM_001025109 NM_001773 NM_001111059 NM_133654 RefSeq (protein) NP_001020280 NP_001764 NP_001104529 NP_598415 Location (UCSC) Chr 1: 207.88 – 207.91 Mb Chr 1: 194.62 – 194.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 ...
Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene. [5] [6] [7] In addition, tetherin has been designated as CD317 (cluster of differentiation 317). This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in ...