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Halofantrine is a drug used to treat malaria. Halofantrine's structure contains a substituted phenanthrene , and is related to the antimalarial drugs quinine and lumefantrine . Marketed as Halfan , halofantrine is never used to prevent malaria and its mode of action is unknown, although a crystallographic study showed that it binds to hematin ...
Artemisinin (/ ˌ ɑːr t ɪ ˈ m iː s ɪ n ɪ n /) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. [1] It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. [2]
The life cycle of malaria parasites: Sporozoites are introduced by a mosquito bite. When they reach the liver, they multiply into thousands of merozoites. The merozoites infect red blood cells and replicate, infecting more and more red blood cells. Some parasites form gametocytes, which are taken up by a mosquito, continuing the life cycle.
Dihydroartemisinin is used to treat malaria, generally as a combination drug with piperaquine. [3] In a systematic review of randomized controlled trials, both dihydroartemisinin-piperaquine and artemether-lumefantrine are very effective at treating malaria (high quality evidence). However, dihydroartemisinin-piperaquine cures slightly more ...
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women. [1]
A Type 1 vaccine is suggested for those exposed mostly to P. falciparum malaria in sub-Saharan Africa, with the primary objective to reduce the number of severe malaria cases and deaths in infants and children exposed to high transmission rates. The Type 2 vaccine could be thought of as a 'travelers' vaccine,' aiming to prevent all clinical ...
Artemether is a medication used for the treatment of malaria. [1] [2] The injectable form is specifically used for severe malaria rather than quinine. [2] In adults, it may not be as effective as artesunate. [2] It is given by injection in a muscle. [2] It is also available by mouth in combination with lumefantrine, known as artemether ...
Proguanil, also known as chlorguanide and chloroguanide, is a medication used to treat and prevent malaria. [3] [4] It is often used together with chloroquine or atovaquone.[4] [3] When used with chloroquine the combination will treat mild chloroquine resistant malaria. [3]