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In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. [1] In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid). [7] In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor).
At the molecular level, HD results from a mutation in the huntingtin protein (Htt). More specifically, there is an abnormal repetition of a CAG sequence towards the 5’-end of the gene, which then leads to the development of a toxic polyglutamine (polyQ) stretch in the protein. The mutated Htt protein affects an individual's proper neural ...
In addition to the transcriptional repressor (corepressor) discussed above, there is a longer isoform that is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD + binding domain similar to NAD + -dependent 2-hydroxyacid dehydrogenases .
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
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66556 Ensembl ENSG00000175550 ENSMUSG00000024914 UniProt Q14919 Q9D6N5 RefSeq (mRNA) NM_006442 NM_001291080 NM_024176 RefSeq (protein) NP_006433 NP_001278009 NP_077138 Location (UCSC) Chr 11: 65.92 – 65.92 Mb Chr 19: 5.47 – 5.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene. Transcriptional ...