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  2. NFKB1 - Wikipedia

    en.wikipedia.org/wiki/NFKB1

    Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. [ 5 ] This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein.

  3. NF-κB - Wikipedia

    en.wikipedia.org/wiki/NF-κB

    Schematic diagram of NF-κB protein structure. [1] There are two structural classes of NF-κB proteins: class I (top) and class II (bottom). Both classes of proteins contain a N-terminal DNA-binding domain (DBD), which also serves as a dimerization interface to other NF-κB transcription factors and, in addition, binds to the inhibitory IκBα ...

  4. NFKB2 - Wikipedia

    en.wikipedia.org/wiki/NFKB2

    NF-κB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-κB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial ...

  5. IKK2 - Wikipedia

    en.wikipedia.org/wiki/IKK2

    IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB.

  6. NFKBID - Wikipedia

    en.wikipedia.org/wiki/NFKBID

    NFKBID is a nuclear protein with 327 amino acids. It contains six ankyrin repeats (ANKs), that are surrounded by a nuclear localization signal sequence (NLS) at the N-terminus and a short C-terminus. [6] [7] The ANKs are characteristic for all IκB proteins. The NLS is an additional characteristic structural element of only atypical IκB ...

  7. NEMO deficiency syndrome - Wikipedia

    en.wikipedia.org/wiki/NEMO_deficiency_syndrome

    Nuclear factor-kappa B Essential Modulator (NEMO) deficiency syndrome is a rare type of primary immunodeficiency disease that has a highly variable set of symptoms and prognoses. It mainly affects the skin and immune system but has the potential to affect all parts of the body, including the lungs , urinary tract and gastrointestinal tract . [ 1 ]

  8. NF-kappa-B-activating protein - Wikipedia

    en.wikipedia.org/wiki/NF-kappa-B-activating_protein

    67050 Ensembl ENSG00000101882 ENSMUSG00000016409 UniProt Q8N5F7 Q9D0F4 RefSeq (mRNA) NM_024528 NM_025937 RefSeq (protein) NP_078804 NP_080213 Location (UCSC) Chr X: 119.92 – 119.94 Mb Chr X: 36.39 – 36.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene. References ^ a b c GRCh38: Ensembl release ...

  9. CHUK - Wikipedia

    en.wikipedia.org/wiki/CHUK

    Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. [5] IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. [6]