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A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) which stabilizes the fold. The term zinc finger was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA.
The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22.
Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. [3] [4] This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [4]
12192 Ensembl ENSG00000185650 ENSMUSG00000021127 UniProt Q07352 P23950 RefSeq (mRNA) NM_004926 NM_001244698 NM_001244701 NM_007564 RefSeq (protein) NP_001231627 NP_001231630 NP_004917 NP_031590 Location (UCSC) Chr 14: 68.79 – 68.8 Mb Chr 12: 80.15 – 80.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Butyrate response factor 1 is a protein that in humans is encoded by the ...
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome ().It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers.
Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. [5] [6] [7] This protein is a member of Ikaros family of transcription factors.[8]This gene encodes a member of the Ikaros family of zinc-finger proteins.
The KRAB domain had initially been identified in 1988 as a periodic array of leucine residues separated by six amino acids 5’ to the zinc finger region of KOX1/ZNF10 [7] coined heptad repeat of leucines (also known as a leucine zipper). [8] Later, this domain was named in association with the C2H2-Zinc finger proteins Krüppel associated box ...
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.
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