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6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
[5] [22] [1] [4] In fact, there may even be sensitization to the effects of 5-MeO-DMT. [4] The lack of tolerance development with 5-MeO-DMT may be due to biased agonism of the serotonin 5-HT 2A receptor. [5] More specifically, 5-MeO-DMT activates the G q signaling pathway of the serotonin 5-HT 2A receptor with much less potency in recruiting β ...
[165] [167] [168] Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT 2A receptor, with minimal β-arrestin2 recruitment, and likewise has been associated with little tolerance to its hallucinogenic effects. [169] [142] As DMT has been shown to have slightly better efficacy (EC 50) at human serotonin 2C receptor than at the 2A ...
[1] α,N-DMT is known to be a potent monoamine oxidase inhibitor and tryptamine or serotonin receptor antagonist. [2] [1] Close analogues of α,N-DMT, such as α-methyltryptamine (αMT), are known to act as monoamine releasing agents and serotonin receptor agonists. [3] α,N-DMT is the N-methylated analogue of αMT. [1]
2,N,N-trimethyltryptamine, 2,N,N-TMT, or 2-Me-DMT is a tryptamine derivative that is a psychedelic drug. It was invented by Alexander Shulgin and reported in his book TiHKAL (#34). [ 1 ]
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Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi , plants and animals ; and sometimes used by humans for the neurological or psychotropic effects of the substance.
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