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β thalassemia major (Mediterranean anemia or Cooley anemia) is caused by a β o /β o genotype. No functional β chains are produced, and thus no hemoglobin A can be assembled. This is the most severe form of β-thalassemia. β thalassemia intermedia is caused by a β + /β o or β + /β + genotype. In this form, some hemoglobin A is produced.
Thalassemia results in nontransferrin-bound iron being available in blood as all the transferrin becomes fully saturated. This free iron is toxic to the body since it catalyzes reactions that generate free hydroxyl radicals. [6] These radicals may induce lipid peroxidation of organelles like lysosomes, mitochondria, and sarcoplasmic membranes.
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is an inherited blood disorder and a form of thalassemia. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin , the molecule that carries oxygen in the blood. [ 4 ]
Throughout her life, Izadyar had many notable achievements. She was the founder of the Iranian Thalassemia Society, [5] co-founder of Iranian Pediatric Hematology-Oncology Society and member of its executive board, a professor at Shahid Beheshti University of Medical Sciences, a pediatrician, a hematologist-oncologist, the chairwoman of the Iranian Thalassemia Society's board of directors, a ...
Beta-thalassemia; Other names: Microcytemia, beta type [1] Beta thalassemia genetics, the picture shows one example of how beta thalassemia is inherited. The beta globin gene is located on chromosome 11. A child inherits two beta globin genes (one from each parent). Specialty: Hematology: Types: Thalassemia minor, intermediate and major [2] Causes
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In 2010 she performed gene therapy on a child with beta thalassemia. [7] [8] [9] Children who are born with Thalassemia Major often develop anaemia within their first years of life. [5] Cavazzana went on to provide gene therapy to sickle cell disease in 2014 [5] and the first patient with Wiskott–Aldrich syndrome. [10]
She co-authored over 60 journal articles and book chapters, and over 80 conference articles and proceedings. She has researched and published in the genetics of some non-communicable diseases such as breast cancers, asthma, malaria and specifically the haemoglobinopathies of sickle cell disease and the thalassaemias and other genetic modifiers.
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