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The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
The Golgi apparatus (also known as the Golgi body and the Golgi complex) is composed of separate sacs called cisternae. Its shape is similar to a stack of pancakes. The number of these stacks varies with the specific function of the cell. The Golgi apparatus is used by the cell for further protein modification.
The cell bodies of Golgi type I neurons are medium-to-large. [24] A Golgi type I neuron has a long axon that begins in the grey matter of the central nervous system and may extend from there. Their cell bodies were mostly multipolar, yet occasionally they might have been triangular in shape and lacking any appendages or spines.
Golgi apparatus: The primary function of the Golgi apparatus is to process and package the macromolecules such as proteins and lipids that are synthesized by the cell. Lysosomes and peroxisomes: Lysosomes contain digestive enzymes (acid hydrolases). They digest excess or worn-out organelles, food particles, and engulfed viruses or bacteria.
The Golgi apparatus plays a pivotal role in N-linked glycosylation, a process that begins in the ER and is elaborated within the Golgi. Through the sequential trimming and addition of sugars like GlcNAc, mannose, galactose, and sialic acid, the Golgi ensures that proteins are properly modified for their final functional roles.
Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. Endosomes can be classified as early, sorting, or late depending on their stage post internalization. [1] Endosomes represent a major sorting compartment of the endomembrane system in cells. [2]
Their cytoplasm also contains a pale zone that on electron microscopy contains an extensive Golgi apparatus and centrioles. Abundant rough endoplasmic reticulum combined with a well-developed Golgi apparatus makes plasma cells well-suited for secreting immunoglobulins. [4]
Lysosomes contain more than 60 different enzymes, and have more than 50 membrane proteins. [8] [9] Enzymes of the lysosomes are synthesized in the rough endoplasmic reticulum and exported to the Golgi apparatus upon recruitment by a complex composed of CLN6 and CLN8 proteins.