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The hook effect refers to the prozone phenomenon, also known as antibody excess, or the postzone phenomenon, also known as antigen excess. It is an immunologic phenomenon whereby the effectiveness of antibodies to form immune complexes can be impaired when concentrations of an antibody or an antigen are very high.
Medical providers often struggle to 'rule out' pregnancy for medical testing or treatment that cannot be conducted during pregnancy before they can do an accurate urine pregnancy test. [ 27 ] More rare, false negative results can also occur due to a " hook effect ", where a sample with a very high level of hCG is tested without dilution ...
The term "rabbit test" was first recorded in 1949, and was the origin of a common euphemism, "the rabbit died", for a positive pregnancy test. [4] The phrase was, in fact, based on a common misconception about the test. While many people assumed that the injected rabbit would die only if the woman was pregnant, in fact all rabbits used for the ...
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Before immunological pregnancy tests were developed in the 1960s, women relied on urine-based pregnancy tests using animals, ranging from mice to frogs. [1] [2] Advancements in medical technology have enabled women to accurately check their pregnancy status by using 'pee-on-a-stick' pregnancy test kits at home. Before these accessible and ...
The increased estrogen in pregnancy leads to increase corticosteroid-binding globulin production and in response the adrenal gland produces more cortisol. [5] The net effect is an increase of free cortisol. This contributes to insulin resistance of pregnancy and possibly striae. [5]
Pregnancy symptoms may be categorized based on trimester as well as region of the body affected. Each pregnancy can be quite different and many people do not experience the same or all of the symptoms. If a person is concerned about their symptoms they should be encouraged to speak with an appropriate healthcare professional. [1]
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