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1401 12944 Ensembl ENSG00000132693 ENSMUSG00000037942 UniProt P02741 P14847 RefSeq (mRNA) NM_000567 NM_001329057 NM_001329058 NM_001382703 NM_007768 RefSeq (protein) NP_000558 NP_001315986 NP_001315987 NP_001369632 NP_031794 Location (UCSC) Chr 1: 159.71 – 159.71 Mb Chr 1: 172.53 – 172.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse C-reactive protein (CRP) is an annular (ring ...
The serum C reactive protein, erythrocyte sedimentation rate, and ferritin level are markedly elevated. In children, a ferritin above 10000 μg/L is very sensitive and specific for the diagnosis of HLH, [17] however, the diagnostic utility for ferritin is less for adult HLH patients. [18]
However, there have been cases of isolated attacks as a result of drug reactions (i.e., use of blocking antibody ipilimumab) [3] [4] or idiopathic events that have presented symptoms which may disappear after relatively short term treatment (i.e., 1 year on corticoids or other immune suppressants). [5]
Blood tests may show elevated creatinine and urea levels (in kidney involvement), raised IgA levels (in about 50% [12]), and raised C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) results; none are specific for Henoch–Schönlein purpura.
Furthermore, it has been discovered that children with adenoid hypertrophy had higher levels of proinflammatory cytokines, including interferon-γ (IFN-γ), high-sensitivity C reactive protein, IL-1 and IL-10, TNF-α (tumor necrosis factor α), and intercellular adhesion molecule-1. [7]
Inflammation also is characterized by high systemic levels of acute-phase proteins. In acute inflammation, these proteins prove beneficial; however, in chronic inflammation, they can contribute to amyloidosis. [9] These proteins include C-reactive protein, serum amyloid A, and serum amyloid P, which cause a range of systemic effects including: [9]
In contrast, C-reactive protein (with a half-life of 6–8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. For example, in active systemic lupus erythematosus, one may find a raised ESR but normal C-reactive protein. [citation needed] They may also indicate liver failure. [11]
C-reactive protein is usually elevated although not commonly measured in the United States. [1] Bilirubin levels are often mildly elevated (1–4 mg/dL). [14] If bilirubin levels are more significantly elevated, alternate or additional diagnoses should be considered such as gallstone blocking the common bile duct (common bile duct stone). [1]